A STUDY OF CERVICAL EPITHELIAL CHANGES, DNA DAMAGE ASSESSMENT ANDCHROMOSOME ABERRATIONS IN PATIENTS WITH CERVICAL INFECTIONS AND MALIGNANCY PROBLEMS
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Abstract
Cervical cancer is a very common malignancy in Indian women. About twenty in 100,000 women are reported to be suffering from the disease. This is mainly due to lack of basic personal hygiene and ignorance about other risk factors among the women of low socio-economic strata who are more susceptible to this disease. Hence a study of some parameters which point towards its early detection is of great value. The present study gives some data on micronucleate, binucleate and other abnormal cells in the cervical epithelium smear scans in patients with leucorrhoea(n=6) and the same from some patients who had cervical malignancies (n-4). DNA damage studies by the comet assaywere also done. The cervical epithelial cells of cancer patients were classified in to 9 categories according to the degree of damage. The chromosome aberrationswere also studied by lymphocyte culture. In the patients with white discharge the mean CA % ± SE was 1.5±1.22. In the cancer patients almost all the lymphocytes were dividing and showed much clumping of metaphase plates. It was found that the parameters examined from cervical smears, their DNA damage data from comet assay and their chromosome aberration studies provide helpful data towards pointing out cases susceptible to malignant changes in the cervix.References
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